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MYP_108147
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Basic Information
P4(SARS-CoV (1153-1182))
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C143H245N41O49
Standard
Sequence
GINASVVNIQKEIDRLNEVAKNLNESLIDL
Physicochemical Analysis
3322.72 Da
4.51
-2.23
-2.44
-0.0744
-0.11
0.70
0.00
31.81
139.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1506.66
-15.84
49.0
47.0
118.0
233.0
0.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037090 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:inhibition of cell fusion in Hela cells
0.8±0.21 μM
IC50
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0043929 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Fusion inhibition
SARS-CoV | of cell; Hela cells
0.8±0.21 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK. | Antiviral Res. 2009 Jan;81(1):82-7. | DOI:10.1016/j.antiviral.2008.10.001 | PMID:18983873 PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0090920 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
2.28 μM
IC50
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0109272 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
SARS coronavirus (Virus entry); HeLa
0.8 μM
beta-galactosidase activity
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK. | Antiviral Res. 2009 | PMID:18983873 PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0136340 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
No discernable cytotoxicity on HeLa or VeroE6 cells at the concentrations of 25 μM
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
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