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MYP_108137
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Basic Information
Antimicrobial peptide VGF[554-577]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Regulatory peptide ▸ Biological regulation
Standard
24 amino acids
C130H199N45O31
Standard
Sequence
TLQPPSALRRRHYHHALPPSRHYP
Physicochemical Analysis
2888.25 Da
11.55
3.74
3.35
0.1560
-1.34
0.42
-0.31
198.05
57.08
0.0833
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1195.23
-11.30
42.0
39.0
82.0
206.0
11.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0068384 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
VGF
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide precursor Secretory granule peptide
PMID23250050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23250050/
RECORD: Rec_0088952 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
P. pastoris GS115
PMID23250050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23250050/
RECORD: Rec_0115031 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0257079 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Antimicrobial peptide VGF[554-577]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation
Mammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Antimicrobial peptide VGF[554-577] (Homo sapiens): PMID 23250050 PMID23250050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23250050/
RECORD: Rec_0272721 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Micrococcus luteus
alamarBlue assay
PMID23250050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23250050/