Peptide Database

Peptide NameCliotide T1

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC453H700N124O136S13

DescriptionStandard

        GIPCGESCVFIPCITGAIGCSCKSKVCYRNHVIAAEAKTMDDHHLLCQSHEDCITKGTGNFCAPFPDQDIKYGWCFRAESEGFMLKDHLKMSITN
    

Molecular Weight10476.00 Da

Isoelectric Point (pI)6.18

Net Charge (pH 7.0)-1.89

Net Charge (pH 7.4) -2.52

Charge Density (pH 7.0) -0.0199

GRAVY Index-0.11

Hydrophobic Moment 0.45

Boman Index0.07

Instability Index27.22

Aliphatic Index 64.74

Aromaticity 0.0842

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 9105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4117.43

LogP -42.48

H-bond Donors 150.0

H-bond Acceptors 152.0

Rotatable Bonds 343.0

Heavy Atoms 726.0

Ring Count 18.0

Amide Bonds 99.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0117730 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Animal]

FamilyCyclotide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defense peptide Anti-Gram-negative Cytolytic Cytotoxic Hemolytic

TargetK. pneumoniae (Gram-negative)

RECORD: Rec_0237541 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Animal]

FamilyCyclotide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defense peptide Anti-Gram-negative Cytolytic Cytotoxic Hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0307222 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Animal]

FamilyCyclotide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defense peptide Anti-Gram-negative Cytolytic Cytotoxic Hemolytic

TargetEscherichia coli (Gram-negative)