Peptide Database

Peptide NameSLAY-screened peptide P2878

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC47H77N17O16

DescriptionStandard

        NISHISKNHS
    

Molecular Weight1136.22 Da

Isoelectric Point (pI)8.76

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.63

Charge Density (pH 7.0) 0.0934

GRAVY Index-1.07

Hydrophobic Moment 0.37

Boman Index-0.16

Instability Index96.88

Aliphatic Index 78.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 555.47

LogP -8.36

H-bond Donors 19.0

H-bond Acceptors 19.0

Rotatable Bonds 38.0

Heavy Atoms 80.0

Ring Count 2.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0364287 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/