Peptide Database

Peptide NameBivalirudin

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Thrombin inhibition ▸ Thrombin inhibitory

Hemostasis ▸ Anticoagulant activity

Hemostasis ▸ Antithrombotic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC98H138N24O33

DescriptionStandard

        FPRPGGGGNGDFEEIPEEYL
    

Molecular Weight2180.29 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-4.23

Net Charge (pH 7.4) -4.44

Charge Density (pH 7.0) -0.2114

GRAVY Index-0.98

Hydrophobic Moment 0.36

Boman Index0.03

Instability Index77.45

Aliphatic Index 39.00

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 901.57

LogP -8.12

H-bond Donors 28.0

H-bond Acceptors 29.0

Rotatable Bonds 66.0

Heavy Atoms 155.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008788 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCoagulation factor

Tax ID32630

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor replacement Enzyme replacement Anticoagulant

Half-LifeNormal renal function: 0.42 hours (in normal conditions)

RECORD: Rec_0045351 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyEnzyme

Tax ID32630

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme replacement Anticoagulant

Half-LifeCreatinine clearance 10-29mL/min: 0.95 hours

RECORD: Rec_0117437 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDirect thrombin inhibitor peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticoagulant Antithrombotic Direct thrombin inhibitor

Half-LifeDialysis-dependant patients: 3.5 h

RECORD: Rec_0356293 VERIFIED: YES

Provenance & Taxonomy

OrganismHirudo medicinalis [Animal]; synthetic construct [Synthetic]

FamilyHirudin analogue

Tax ID6421;32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Anticoagulant Antithrombotic

TargetHuman thrombin

Half-LifeClinical/Human: 25 min (up to 3.5 h for dyalisis-dependant patients)