Peptide Database

Peptide NameHc-15(Derived from Hc-CATH)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC88H154N28O17

DescriptionStandard

        FKRLLKSVRRAVKKF
    

Molecular Weight1876.34 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.4504

GRAVY Index-0.43

Hydrophobic Moment 0.99

Boman Index-0.43

Instability Index51.65

Aliphatic Index 97.33

Aromaticity 0.1333

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 780.73

LogP -4.61

H-bond Donors 30.0

H-bond Acceptors 24.0

Rotatable Bonds 68.0

Heavy Atoms 133.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0408259 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHc-CATH

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetShigella dysenteriae(CI)

Activity4.69 μg/mL

MethodMIC

Paper青环海蛇抗菌肽Hc-CATH的分子设计及药效毒理优化; Molecular design, pharmacology and toxicology optimization of antimicrobial peptide from Hydrophis cyanocinctus, Hc-CATH. [J].生物工程学报,2021,37(07):2534-2542. DOI:10.13345/j.cjb.200583. PMID34327918 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34327918/

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