Peptide Database

Peptide NameInterleukin-6

Function Ontology

Antiviral

Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide

Immunology ▸ Immune modulation ▸ Cytokine modulation

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic

Standard StatusStandard

Sequence Length183 amino acids

Chemical FormulaC909H1475N253O286S9

DescriptionStandard

        VPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
    

Molecular Weight20812.54 Da

Isoelectric Point (pI)6.21

Net Charge (pH 7.0)-1.09

Net Charge (pH 7.4) -1.52

Charge Density (pH 7.0) -0.0060

GRAVY Index-0.50

Hydrophobic Moment 0.79

Boman Index-0.10

Instability Index57.89

Aliphatic Index 84.81

Aromaticity 0.0601

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10220.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8828.78

LogP -108.83

H-bond Donors 303.0

H-bond Acceptors 296.0

Rotatable Bonds 705.0

Heavy Atoms 1457.0

Ring Count 21.0

Amide Bonds 206.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084994 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyIL-6 superfamily

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide43-49; 72-82

Other Mods52-Ser: Phosphoserine; by FAM20C

Bio-Activity Profile

Function

Cytokine Growth factor IL-6 superfamily Antiviral Chemokine-like Growth factor signaling Angiogenic Host defense