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MYP_108023
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Basic Information
P6-3
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
20 amino acids
C103H137N25O25S2
Standard
Sequence
DCPNGPWVWVPAFCQAVGWG
Physicochemical Analysis
2189.47 Da
4.05
-1.26
-1.49
-0.0629
0.24
0.30
0.40
13.91
53.50
0.2000
16500.00
16625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
760.70
-4.08
26.0
26.0
56.0
155.0
10.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075506 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 (RU570) | TZM-bl cells
2 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. | Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H. | J Virol. 2011 Jul;85(14):7037-47. | DOI:10.1128/JVI.02366-10 | PMID:21543477 PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0083231 VERIFIED: YES
Provenance & Taxonomy
GB virus C [Virus]
54290
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
TZM-bl
Qualitative inhibition
PaperPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0101292 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1(RU570):inhibition of HIV replication in TZM-bl cells
2 μM
IC50
PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0228277 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 (92UG024) | TZM-bl cells
4 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. | Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H. | J Virol. 2011 Jul;85(14):7037-47. | DOI:10.1128/JVI.02366-10 | PMID:21543477 PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0267642 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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