‹ ›
MYP_108005
← PREVIOUS NEXT → BACK
Basic Information
CHR-1, Env GP (623-658)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
36 amino acids
C196H288N56O67S
Standard
Sequence
WNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQ
Physicochemical Analysis
4532.78 Da
4.53
-5.05
-5.37
-0.1403
-1.56
0.58
-0.24
59.52
54.17
0.1111
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2064.99
-21.98
69.0
65.0
152.0
320.0
9.0
44.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0045487 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition
Human immunodeficiency virus (HIV)
0.02641±0.00055 μM
IC90
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0328332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition
Human immunodeficiency virus (HIV) | MT-2 cells
0.01727±0.00031 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0394263 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0404259 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human immunodeficiency virus (HIV):inhibition of cell-cell fusion in MT-2 cells
0.01727±0.00031 μM
IC50
PaperPubMed PMID: 17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/