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MYP_107997
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Basic Information
MBD-4 (11-40) (P9 [H21R,K23R,K28R], P9R)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C144H232N52O35S5
Standard
Sequence
NGAICWGPCPTAFRQIGNCGRFRVRCCRIR
Physicochemical Analysis
3412.03 Da
10.46
5.71
5.43
0.1903
-0.15
0.74
-0.15
12.80
55.33
0.1000
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1426.33
-16.34
57.0
46.0
107.0
236.0
6.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205537 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin-derived peptide
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
4.2 μg/mL
IC50
PaperA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2 PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0214332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Replication inhibition
SARS-CoV | E6 cells
4.2 μg/mL
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. | Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY. | Nat Commun. 2020 Aug 25;11(1):4252. | DOI:10.1038/s41467-020-17986-9 | PMID:32843628 PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0218373 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human Influenza A Virus H1N1
PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0219815 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV
PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0230494 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
branched peptide architecture [Branched]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Hemolytic
no obvious hemolysis
PMID33750821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33750821/
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