‹ ›
MYP_107997
← PREVIOUS NEXT → BACK
Basic Information
MBD-4 (11-40) (P9 [H21R,K23R,K28R], P9R)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C144H232N52O35S5
Standard
Sequence
NGAICWGPCPTAFRQIGNCGRFRVRCCRIR
Physicochemical Analysis
3412.03 Da
10.46
5.71
5.43
0.1903
-0.15
0.74
-0.15
12.80
55.33
0.1000
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1426.33
-16.34
57.0
46.0
107.0
236.0
6.0
32.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0019093 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Human Influenza A Virus H7N9 | MDCK cells
0.9 μg/mL
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. | Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY. | Nat Commun. 2020 Aug 25;11(1):4252. | DOI:10.1038/s41467-020-17986-9 | PMID:32843628 PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0033142 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:Inhibition of infection in Vero E6 cells
0.9 μg/mL
IC50
PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0046220 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
MERS-CoV
PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0074278 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
the CC50 of P9R
PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
RECORD: Rec_0084495 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
PMID32843628 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32843628/
1 2 3 ... 8 NEXT LAST
Showing 5 records on this page · Page 1 of 8