Peptide Database

Peptide NameNatriuretic peptide HsNP-a

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC137H231N43O45S3

DescriptionStandard

        SGSKTAKIGDGCFGVRLDRIGSTSGMGCGGVPKP
    

Molecular Weight3296.76 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)2.44

Net Charge (pH 7.4) 2.20

Charge Density (pH 7.0) 0.0718

GRAVY Index-0.19

Hydrophobic Moment 0.51

Boman Index0.04

Instability Index12.07

Aliphatic Index 54.41

Aromaticity 0.0294

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1403.88

LogP -20.99

H-bond Donors 52.0

H-bond Acceptors 51.0

Rotatable Bonds 110.0

Heavy Atoms 228.0

Ring Count 3.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0407118 VERIFIED: YES

Provenance & Taxonomy

OrganismHoplocephalus stephensii [Animal]

FamilyNatriuretic peptide HsNP

Tax ID196418

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour