Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2325H3722N590O667S20

DescriptionStandard

        MSPCCWLALLALIPLTLAANPGVKVKLTDKGIEYGMFEIGMASLQQKLKTIKVPDLSGTEKVPPIGKVKYSLTGMTIVNLGLPKSALVLVPDTGVSLAITNAFINLHGNWRVRYFRFIQDSGSFDLAVNGLTITANIAIKSDETGRPTVSSVNCVANVGSARIKFHGGASWLYNLFKSYIDKALRSALQKQICPLVADAITDMNPHLKTFNVLAKVDQYAEIEYSMVTSPTISKSSIEFSLKGEFYNIGKHQEPPFSPTPFSLPPQANNMLYIGVSSFTPNSAGFVYNNAGALSLNVTDDMIPASSPIRLNTGTFGVFIPEVAKRFPGMMMKLLVKTVKEPTISLEPNNVTVQASGTVTAYAIQPNTTLSPLFVLNMEGSVSAQLNVTGVKLAGAITLNKIEMTLGTSYVGQFQVQSLDNIFLMVLKVVVIPKVNARLEKGFPLPSIGKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight51253.27 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)9.82

Net Charge (pH 7.4) 9.25

Charge Density (pH 7.0) 0.0207

GRAVY Index0.21

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index31.89

Aliphatic Index 101.56

Aromaticity 0.0802

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0411347 VERIFIED: NO

Provenance & Taxonomy

OrganismHucho hucho [Bacterium]

FamilyBPI

Tax ID62062

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence