Peptide Database

Peptide NameSLAY-screened peptide P4969

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H149N33O29S3

DescriptionStandard

        CLLNWPQNHCRFCGSHQDWT
    

Molecular Weight2445.72 Da

Isoelectric Point (pI)6.89

Net Charge (pH 7.0)-0.09

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0047

GRAVY Index-0.79

Hydrophobic Moment 0.51

Boman Index-0.07

Instability Index25.69

Aliphatic Index 39.00

Aromaticity 0.1500

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1008.39

LogP -10.36

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 73.0

Heavy Atoms 171.0

Ring Count 8.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032754 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/