‹ ›
MYP_107817
← PREVIOUS NEXT → BACK
Basic Information
B1
Anticancer
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
15 amino acids
C94H159N27O17
Standard
Sequence
VKRFKKFFRKLKKSV
Physicochemical Analysis
1939.44 Da
12.00
7.73
7.51
0.5152
-0.84
0.95
-0.50
7.81
64.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
770.87
-3.44
29.0
25.0
72.0
138.0
3.0
14.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0061265 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562/ADM
10±0.8 μM
IC50
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0074965 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal stearoylation (C18 fatty-acid conjugation)
Amidation
N-terminal stearoylation (C18 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562
3.8±0.1 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0078695 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal stearoylation (C18 fatty-acid conjugation)
Amidation
N-terminal stearoylation (C18 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562/ADM
4.2±0.5 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0086678 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal myristoylation (C14 fatty-acid conjugation)
Amidation
N-terminal myristoylation (C14 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562
11.5±0.9 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0089367 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal decanoylation (C10 fatty-acid conjugation)
Amidation
N-terminal decanoylation (C10 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562/ADM
4.2±0.5 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
FIRST PREV 1 ... 6 7 8 9 10 ... 33 NEXT LAST
Showing 5 records · Page 8 of 33