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MYP_107817
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Basic Information
B1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C94H159N27O17
Standard
Sequence
VKRFKKFFRKLKKSV
Physicochemical Analysis
1939.44 Da
12.00
7.73
7.51
0.5152
-0.84
0.95
-0.50
7.81
64.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
770.87
-3.44
29.0
25.0
72.0
138.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0344204 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)16CO, Octadecanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
K562/ADM
11.7±0.7 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0345499 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)16CO, Octadecanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: MCF-7
3.2±0.2 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0351056 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)8CO, Decanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0355890 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)12CO, Myristic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
K562
6.6±0.3 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0356953 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
CH3(CH2)16CO, Octadecanoic acid
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: <20% Hemolysis =160 μM
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
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