Peptide Database

Peptide NameB1

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC94H159N27O17

DescriptionStandard

        VKRFKKFFRKLKKSV
    

Molecular Weight1939.44 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.73

Net Charge (pH 7.4) 7.51

Charge Density (pH 7.0) 0.5152

GRAVY Index-0.84

Hydrophobic Moment 0.95

Boman Index-0.50

Instability Index7.81

Aliphatic Index 64.67

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 770.87

LogP -3.44

H-bond Donors 29.0

H-bond Acceptors 25.0

Rotatable Bonds 72.0

Heavy Atoms 138.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0345499 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal stearoylation (C18 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal stearoylation (C18 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetMCF-7

Activity3.2±0.2 μM

MethodIC50

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0351056 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal decanoylation (C10 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal decanoylation (C10 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic Hemolytic

TargetMCF-7; MCF-7/Taxol; K562; K562/ADM; HeLa; GES-1; HEK293T; human erythrocytes

MethodMTT cell-viability and hemolysis assays

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0355890 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal myristoylation (C14 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal myristoylation (C14 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetK562

Activity6.6±0.3 μM

MethodIC50

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0356953 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal stearoylation (C18 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal stearoylation (C18 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

Targethuman erythrocytes

Activity<20 %

MethodHemolysis at 160 μM

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0360263 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal decanoylation (C10 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal decanoylation (C10 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetK562

Activity3.9±0.2 μM

MethodIC50

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

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