Peptide Database

Peptide NameB1

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC94H159N27O17

DescriptionStandard

        VKRFKKFFRKLKKSV
    

Molecular Weight1939.44 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.73

Net Charge (pH 7.4) 7.51

Charge Density (pH 7.0) 0.5152

GRAVY Index-0.84

Hydrophobic Moment 0.95

Boman Index-0.50

Instability Index7.81

Aliphatic Index 64.67

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 770.87

LogP -3.44

H-bond Donors 29.0

H-bond Acceptors 25.0

Rotatable Bonds 72.0

Heavy Atoms 138.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0314368 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal stearoylation (C18 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal stearoylation (C18 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetMCF-7/Taxol

Activity2±0.1 μM

MethodIC50

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0315018 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal myristoylation (C14 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal myristoylation (C14 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetMCF-7

Activity3.2±0.2 μM

MethodIC50

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0316067 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal decanoylation (C10 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal decanoylation (C10 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

Targethuman erythrocytes

Activity<20 %

MethodHemolysis at 160 μM

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

RECORD: Rec_0322687 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetMCF-7/Taxol

Activity57.6±6.3 μM

MethodIC50

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0323734 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical chemical modification [Modified]

N-TermN-terminal palmitoylation (C16 fatty-acid conjugation)

C-TermAmidation

Other ModsN-terminal palmitoylation (C16 fatty-acid conjugation)

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

TargetK562/ADM

Activity4.9±0.1 μM

MethodIC50

PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/

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