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MYP_107817
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Basic Information
B1
Anticancer
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
15 amino acids
C94H159N27O17
Standard
Sequence
VKRFKKFFRKLKKSV
Physicochemical Analysis
1939.44 Da
12.00
7.73
7.51
0.5152
-0.84
0.95
-0.50
7.81
64.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
770.87
-3.44
29.0
25.0
72.0
138.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0101287 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal stearoylation (C18 fatty-acid conjugation)
Amidation
N-terminal stearoylation (C18 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7
9.1±0.7 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0105029 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal lauroylation (C12 fatty-acid conjugation)
Amidation
N-terminal lauroylation (C12 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562
27±2.1 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0113129 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical chemical modification [Modified]
N-terminal lauroylation (C12 fatty-acid conjugation)
Amidation
N-terminal lauroylation (C12 fatty-acid conjugation)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7/Taxol
2±0.3 μM
IC50
PaperAliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org Biomol Chem. 2015;13(28):7673-7680. doi: 10.1039/C5OB00752F. PMID: 26083110. PMID26083110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26083110/
RECORD: Rec_0115635 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
MCF-7; MCF-7/Taxol; K562; K562/ADM; HeLa; GES-1; HEK293T; human erythrocytes
MTT cell-viability and hemolysis assays
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0118087 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
K562
11.5±0.9 μM
IC50
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
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