Peptide Database

Peptide NameSLAY-screened peptide P4350

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC75H115N17O25S2

DescriptionStandard

        SEQSVKCPSPYYLSM
    

Molecular Weight1718.94 Da

Isoelectric Point (pI)5.72

Net Charge (pH 7.0)-0.55

Net Charge (pH 7.4) -0.78

Charge Density (pH 7.0) -0.0367

GRAVY Index-0.50

Hydrophobic Moment 0.29

Boman Index0.00

Instability Index125.59

Aliphatic Index 45.33

Aromaticity 0.1333

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 680.93

LogP -7.29

H-bond Donors 24.0

H-bond Acceptors 27.0

Rotatable Bonds 52.0

Heavy Atoms 119.0

Ring Count 4.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084803 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/