Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2309H3651N575O691S17

DescriptionStandard

        MLLSVTVVLSLLSCVCGENPAVQVVLTNKGLQYGKHAAADWIQERLSTITFPDITGSVHIVFGDVDYTLTGITIVKCDLPEPSVEFLQNPPGFKTTISDLSIAITGGWRTHFGLINDGGTFDMAIFNVDVTSVVQLGKEADGHLSVSSISCDAQVGDVDIEFHGGASFIFQPFVEHFKGRIRDEIQKRLCPGVEENIESFENLLHVMNVSVDVNEVLSLALPLTDIPIIGASSMNVGLKGEFYNIKAPVEPPFEAQPFTMPDEPSYMLSVGMSDFTLNSASYAYFSAKLLQLLINDSMIPAISPVHLNTTSLGKFIPKLAEMYPDMLMSVLVYAQEAPNFSIQPDAVNVTIKAVAKASVILPNGTQIPVFTINVDSKFSSELWIDDGKLKGSVKMDNLTLTLASSEVGTFKTDSLEFLARKGGEIVLIRVNQKLGEGFLVLGTKHAQLVNSVLKKEKGFILISSDVQVSLT
    

Molecular Weight51067.23 Da

Isoelectric Point (pI)4.81

Net Charge (pH 7.0)-19.70

Net Charge (pH 7.4) -20.55

Charge Density (pH 7.0) -0.0418

GRAVY Index0.24

Hydrophobic Moment 0.64

Boman Index0.20

Instability Index33.82

Aliphatic Index 105.05

Aromaticity 0.0786

Extinction Coeff. Reduced 28420.00

Extinction Coeff. Oxidized 28670.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0324430 VERIFIED: NO

Provenance & Taxonomy

OrganismHaplochromis burtoni [Bacterium]

FamilyBPI

Tax ID8153

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence