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MYP_107686
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Basic Information
Brevinin-2GHk
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C150H245N43O42S2
Standard
Sequence
GFSSLFKAGAKYLLKQVGKAGAQQLACKAANNC
Physicochemical Analysis
3386.94 Da
9.79
4.73
4.49
0.1435
0.03
0.61
0.09
21.27
77.27
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1400.76
-16.11
49.0
49.0
117.0
237.0
3.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0268362 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli NCTC 10418
512 μM
MIC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
RECORD: Rec_0275376 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecalis NCTC 12697
64 μM
MIC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
RECORD: Rec_0280208 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecalis NCTC 12697
256 μM
MBC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
RECORD: Rec_0322676 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Sylvirana guentheri [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Klebsiella pneumoniae
>512 μM
MIC
PaperBrevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity
RECORD: Rec_0349175 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 27853
512 μM
MIC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
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