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MYP_107686
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Basic Information
Brevinin-2GHk
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C150H245N43O42S2
Standard
Sequence
GFSSLFKAGAKYLLKQVGKAGAQQLACKAANNC
Physicochemical Analysis
3386.94 Da
9.79
4.73
4.49
0.1435
0.03
0.61
0.09
21.27
77.27
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1400.76
-16.11
49.0
49.0
117.0
237.0
3.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209292 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli NCTC 10418
512 μM
MBC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
RECORD: Rec_0229741 VERIFIED: YES
Provenance & Taxonomy
Fejervarya limnocharis [Animal]
Brevinin
110108
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-ZIKV Infection inhibition
Zika virus | Vero cells
3.408±0.738 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperBrevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity. | Xiong W, Li J, Feng Y, Chai J, Wu J, Hu Y, Tian M, Lu W, Xu X, Zou M. | Viruses. 2021 Nov 28;13(12):2382. | DOI:10.3390/v13122382 | PMID:34960651 PMID34960651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34960651/
RECORD: Rec_0236386 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans NCYC 1467
256 μM
MIC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
RECORD: Rec_0261288 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Sylvirana guentheri [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Staphylococcus aureus
64 μM
MIC
PaperBrevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity
RECORD: Rec_0266186 VERIFIED: YES
Provenance & Taxonomy
Fejervarya limnocharis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID34960651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34960651/
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