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MYP_107686
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Basic Information
Brevinin-2GHk
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C150H245N43O42S2
Standard
Sequence
GFSSLFKAGAKYLLKQVGKAGAQQLACKAANNC
Physicochemical Analysis
3386.94 Da
9.79
4.73
4.49
0.1435
0.03
0.61
0.09
21.27
77.27
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1400.76
-16.11
49.0
49.0
117.0
237.0
3.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012189 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Sylvirana guentheri [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Inactive: MRSA, Escherichia coli
>512 μM
MIC
PaperBrevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity
RECORD: Rec_0015179 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus NCTC 10788
256 μM
MBC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
RECORD: Rec_0027288 VERIFIED: YES
Provenance & Taxonomy
Fejervarya limnocharis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
PMID34960651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34960651/
RECORD: Rec_0066488 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Sylvirana guentheri [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Candida albicans
>256 μM
MIC
PaperBrevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity
RECORD: Rec_0080972 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus NCTC 12493
512 μM
MIC
PMID32075067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32075067/
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