Peptide Database

Peptide NameLL-37 (13-32)[I13G,G14I,E16Q]

Function Ontology

Anticancer

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H195N35O26

DescriptionStandard

        GIKQFKRIVQRIKDFLRNLV
    

Molecular Weight2471.99 Da

Isoelectric Point (pI)11.73

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.55

Charge Density (pH 7.0) 0.2379

GRAVY Index-0.23

Hydrophobic Moment 0.99

Boman Index-0.21

Instability Index21.39

Aliphatic Index 126.50

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1046.55

LogP -6.67

H-bond Donors 37.0

H-bond Acceptors 31.0

Rotatable Bonds 89.0

Heavy Atoms 175.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423555 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic Anticancer

TargetCEM-SS cells

Activity13

MethodTC50

PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. Antimicrob Agents Chemother. 2008 Sep;52(9):3438-3440. doi: 10.1128/AAC.00452-08. PMID: 18591279. PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/

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