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MYP_107574
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Basic Information
LL-37
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
37 amino acids
C205H340N60O53
Standard
Sequence
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
4493.26 Da
10.61
5.76
5.55
0.1558
-0.72
0.97
-0.31
23.34
89.46
0.1081
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1901.12
-14.63
68.0
59.0
161.0
318.0
5.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055094 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus aureus ATCC 25923
2.227 μM
Crystal violet assay
RECORD: Rec_0063023 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal] [Animal]; Pan troglodytes [Animal]
Cathelicidin
9606;9598
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
Bio-Activity Profile
Antiviral Anti-EBOV Entry inhibition
Ebola Virus(EBOV) | Hela cells
4.03 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperEngineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection. | Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K. | iScience. 2020 Apr 24;23(4):100999. | DOI:10.1016/j.isci.2020.100999 | PMID:32252021 PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0069002 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal] [Animal]; Pan troglodytes [Animal]
Cathelicidin
9606;9598
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1
2.5 μM
% inhibition
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperComparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Roy M, Lebeau L, Chessa C, Damour A, Ladram A, Oury B, Boutolleau D, Bodet C, Lévêque N. | Viruses. 2019 Jan 18;11(1):77. | DOI:10.3390/v11010077 | PMID:30669255 PMID30669255 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30669255/
RECORD: Rec_0070069 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa
142.521 μM
Total countable CFUs
RECORD: Rec_0072616 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unformulated, A = 5 and B = 10 mg/mL particles
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
8-16 μg/mL
MIC
PMID28476579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28476579/
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