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MYP_107574
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Basic Information
LL-37
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
37 amino acids
C205H340N60O53
Standard
Sequence
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
4493.26 Da
10.61
5.76
5.55
0.1558
-0.72
0.97
-0.31
23.34
89.46
0.1081
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1901.12
-14.63
68.0
59.0
161.0
318.0
5.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0382017 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Vaccinia virus (Replication); BSC-1
Plaque assay
PaperSelective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. | Howell MD, Jones JF, Kisich KO, Streib JE, Gallo RL, Leung DY. | J Immunol. 2004 | PMID:14734759 PMID14734759 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14734759/
RECORD: Rec_0384022 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unformulated, A = 5 and B = 10 mg/mL particles
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa clinical strain
8 μg/mL
MIC
PMID28476579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28476579/
RECORD: Rec_0385381 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antibiofilm Antibacterial
Burkholderia thailandensis E264/ATCC 700388
66.807, 0, 0.668 μM
OD600; Crystal violet assay
PaperNatural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus
RECORD: Rec_0385832 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa
1.782, 3.563 μM
Crystal violet assay
PaperNatural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus
RECORD: Rec_0388085 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antibiofilm Antibacterial
Burkholderia thailandensis E264/ATCC 700388
11.13 μM
OD600; Crystal violet assay
PaperNatural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus
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