Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length56 amino acids

Chemical FormulaC289H471N89O84S6

DescriptionStandard

        GWIRRCYYGTGRCRKSCKEIERKKEKCGEKHICCVPKEKDKLSHIHDQKETSELYI
    

Molecular Weight6728.77 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)5.97

Net Charge (pH 7.4) 5.50

Charge Density (pH 7.0) 0.1066

GRAVY Index-1.23

Hydrophobic Moment 0.72

Boman Index-0.39

Instability Index56.07

Aliphatic Index 53.93

Aromaticity 0.0714

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2867.19

LogP -27.27

H-bond Donors 109.0

H-bond Acceptors 99.0

Rotatable Bonds 238.0

Heavy Atoms 468.0

Ring Count 9.0

Amide Bonds 56.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006318 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes troglodytes [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KL2/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0086601 VERIFIED: NO