MYP_107519
B1-L-6
Anticancer
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
15 amino acids
C94H158N28O17
Standard
VKRFRKFFRKLSKLV
1952.44 Da
12.00
6.73
6.51
0.4487
-0.37
0.97
-0.39
17.83
90.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
780.73
-3.38
30.0
24.0
70.0
139.0
3.0
14.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0071418
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
U87
4.58±0.93 μM
IC50
RECORD: Rec_0080787
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
5.152±1.04 μM
IC50
RECORD: Rec_0185494
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
Huh-7
5.89±0.43 μM
IC50
RECORD: Rec_0305622
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Hemolytic
human red blood cells
>80 μM
HC50