Peptide Database

Peptide NameAmyS signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC184H288N46O40S3

DescriptionStandard

        MLTFHRIIRKGWMFLLAFLLTASLFCPTGQPAKA
    

Molecular Weight3880.73 Da

Isoelectric Point (pI)11.01

Net Charge (pH 7.0)3.58

Net Charge (pH 7.4) 3.29

Charge Density (pH 7.0) 0.1052

GRAVY Index0.74

Hydrophobic Moment 0.75

Boman Index0.30

Instability Index35.93

Aliphatic Index 103.53

Aromaticity 0.1471

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1350.36

LogP -5.60

H-bond Donors 49.0

H-bond Acceptors 48.0

Rotatable Bonds 123.0

Heavy Atoms 273.0

Ring Count 9.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409041 VERIFIED: YES

Provenance & Taxonomy

OrganismGeobacillus stearothermophilus [Bacterium]

FamilySec signal peptide

Tax ID1422

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization alpha-amylase (AmyS) secretion

TargetBacillus subtilis 1A751p

Activity883.35 U/mL

MethodAmylase activity assay

PaperFu G, Liu J L, Li J S, et al. Systematic Screening of Optimal Signal Peptides for Secretory Production of Heterologous Proteins in Bacillus subtilis[J]. Journal of Agricultural and Food Chemistry, 2018, 66(50): 13141-13151. PMID30463403 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30463403/