Peptide Database

Peptide NameProphenin-2 (C12, PF-2, PR-2; Pro-rich; pigs, mammals, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length79 amino acids

Chemical FormulaC436H589N103O85

DescriptionStandard

        AFPPPNVPGPRFPPPNVPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPPFPPPIFPGPWFPPPPPFRPPPFGPPRFP
    

Molecular Weight8632.98 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.80

Net Charge (pH 7.4) 5.61

Charge Density (pH 7.0) 0.0734

GRAVY Index-0.78

Hydrophobic Moment 0.43

Boman Index0.14

Instability Index91.67

Aliphatic Index 13.54

Aromaticity 0.1899

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2566.58

LogP -10.65

H-bond Donors 62.0

H-bond Acceptors 91.0

Rotatable Bonds 183.0

Heavy Atoms 624.0

Ring Count 58.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087554 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

RECORD: Rec_0095687 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCathelicidin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

C-TermAmidation

Other Mods257). The major forms of PF found in these extracts by nano-ES mass spectrometry are the 80-residue polypeptides prophenin-2-Pyr (PF-2-Pyr) and prophenin-2-Gln (PF-2-Gln). Prophenin-2-Pyr is refractory to Edman degradation due to the presence of an N-terminal pyroglutamic residue. In PF-2-Gln the N-terminal residue is glutamine and the C-terminus is amidated

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0264214 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCathelicidin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0324209 VERIFIED: NO

Provenance & Taxonomy

OrganismSus sp. [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0333461 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetListeria monocytogenes