Peptide Database

Peptide NameSLAY-screened peptide P3545

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H175N35O24S

DescriptionStandard

        RCRPTGLLPRLLPGIFRNHY
    

Molecular Weight2379.83 Da

Isoelectric Point (pI)11.54

Net Charge (pH 7.0)3.84

Net Charge (pH 7.4) 3.57

Charge Density (pH 7.0) 0.1918

GRAVY Index-0.36

Hydrophobic Moment 0.78

Boman Index-0.13

Instability Index54.27

Aliphatic Index 97.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 949.68

LogP -6.98

H-bond Donors 35.0

H-bond Acceptors 30.0

Rotatable Bonds 72.0

Heavy Atoms 168.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303445 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli surface-display system

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/