Peptide Database

Peptide NameP8

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC149H233N33O45S

DescriptionStandard

        SALEEQLKTFLDKFMHELEDLLYQLAL
    

Molecular Weight3238.70 Da

Isoelectric Point (pI)4.35

Net Charge (pH 7.0)-4.44

Net Charge (pH 7.4) -4.71

Charge Density (pH 7.0) -0.1645

GRAVY Index-0.01

Hydrophobic Moment 0.63

Boman Index0.11

Instability Index55.47

Aliphatic Index 122.96

Aromaticity 0.1111

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1271.31

LogP -5.87

H-bond Donors 42.0

H-bond Acceptors 43.0

Rotatable Bonds 112.0

Heavy Atoms 228.0

Ring Count 4.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0251741 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetinhibition of replication in Calu-3 cells

Activity0.046 μM

MethodIC50

RECORD: Rec_0395066 VERIFIED: YES