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MYP_107259
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Basic Information
P8
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
27 amino acids
C149H233N33O45S
Standard
Sequence
SALEEQLKTFLDKFMHELEDLLYQLAL
Physicochemical Analysis
3238.70 Da
4.35
-4.44
-4.71
-0.1645
-0.01
0.63
0.11
55.47
122.96
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1271.31
-5.87
42.0
43.0
112.0
228.0
4.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003444 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0032885 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
0.046 μM
IC50
PaperHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0045016 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Replication inhibition
SARS-CoV-2 | Vero-E6 cells
10 μM
% inhibition
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. | Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O. | Commun Biol. 2021 Feb 12;4(1):197. | DOI:10.1038/s42003-021-01736-8 | PMID:33580154 PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0100522 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
The peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells
PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0127348 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of replication in Calu-3 cells
0.046 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. | Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O. | Commun Biol. 2021 Feb 12;4(1):197. | DOI:10.1038/s42003-021-01736-8 | PMID:33580154 PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
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