Peptide Database

Peptide NameSecretogranin-1

Function Ontology

Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length655 amino acids

Chemical FormulaC3225H4954N980O1121S6

DescriptionStandard

        APVDNRDHNEEMVTRCIIEVLSNALSKSSAPTITPECRQVLRKSGKEVKGEEKGENENSKFEVRLLRDPSDASVGRWASSREETGAPVEDSPGQAKVDNEEWTGGGGHSREAVDDQESLHPSNQQVSKEAKIRHSEERGGKEEEEEEGKIYPKGEHRGDAGEEKKHTEESGEKHNAFSNKRSEASAKKKEESVARAEAHFVELEKTHSREQSSQESGEETRRQEKPQELPDQDQSEEESEEGEEGEEGATSEVTKRRPRHHHWRSQSNKPSYEGRRPLSEERKHAAGESKDANVATANLGEKRGHHLAHYRASEEEPDYGEELRSYPGFQAPQGLQYQGRGSEEVRAPSPRSEESQEKEYKRNHPDSELESTANRHSEETEEERSYEGAKGRQHRGRGREPGAYPALDSRQEKRLLDEGHDPVHESPVDTAKRYPQSKWQEQEKNYLNYDEEGDQGRWWQQEEQLEPEESREEVSFPDRQYAPYPTTEKRKRLGALFNPYFDPLQWKNSDFEKKGNPDDSFLDDDGEDGNGVTMTEKNFFPEYNYDWWEKRPFSEDVNWGYEKRSFARAPHLDLKRQYDDGVAELDQLLHYRKKAAEFPDFYDSEEQMGPHQEAEDEKDRADQRVLTEEEKKELENLAAMDLELQKIAEKFSQRG
    

Molecular Weight75582.12 Da

Isoelectric Point (pI)4.95

Net Charge (pH 7.0)-51.83

Net Charge (pH 7.4) -53.59

Charge Density (pH 7.0) -0.0791

GRAVY Index-1.59

Hydrophobic Moment 0.72

Boman Index-0.37

Instability Index75.63

Aliphatic Index 39.97

Aromaticity 0.0718

Extinction Coeff. Reduced 86290.00

Extinction Coeff. Oxidized 86415.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0326574 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyChromogranin/secretogranin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsSer79 Phosphoserine; Ser80 Phosphoserine; Ser127 Phosphoserine; Tyr151 Sulfotyrosine; Ser235 Phosphoserine; Ser239 Phosphoserine; Ser271 Phosphoserine; Ser289 Phosphoserine; Ser313 Phosphoserine; Tyr319 Sulfotyrosine; Ser352 Phosphoserine; Ser355 Phosphoserine; Ser377 Phosphoserine; Tyr446 Sulfotyrosine; Tyr449 Sulfotyrosine; Ser509 Phosphoserine; Ser520 Phosphoserine; Tyr543 Sulfotyrosine; Tyr545 Sulfotyrosine; Tyr602 Sulfotyrosine; Ser604 Phosphoserine; Arg654 Amidation

Bio-Activity Profile

Function

Secretory granule peptide Neuropeptide precursor