Peptide Database

Peptide NamePyocin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length563 amino acids

Chemical FormulaC2757H4335N831O812S22

DescriptionStandard

        MTYRPDIHGRGMALSCDKTTTGAWLITSLPVPNYNVCGNGLIRKGDKTTPCPACGKPGMVAEGEARFKVIDIPIAVDGCVVHCGCPEGSNRIIAPLGQWMGAGPSPAEIAQKKQAELIAQRRAEREAEEKRREEERERNRVFAKSCLRGAGCNDAGDQREPHTNFAPMGIYQAVPQTDPVTDTEAPQRAQAVKKKKLIAPEDIPKPKKRSALWKWWNGHHEEMDYQRAVEEAERAQRARAAIAGASVLRPVAGNFAIRGTWAVVGETATGVAGLPLAAFLIGMMPGRLNDGEQDFIDRMRAEQVREVPTRVRFTWETNSRGNPVPHGWHTPPGQDRVRVRRMEWDDRRKAYTFTTEEDPRITLIWTPDNPGIDVPYHTGNQYPPVLPNPVMVDPLPDDTGLHATTSPAPEEKDFADYILILPFPDIPPIYIYIRNNAGQVTGKGQKISGAWLVDADKGNGAPVPSQIAERMRGRTFANFDRFREAFWAEVANDADLSRQFRAHNLTNIRKGRSPFTREVDRVGGRERYEIHHIKPISEGGEVYNVDNMGITTPKRHIEIHRGK
    

Molecular Weight62819.43 Da

Isoelectric Point (pI)8.72

Net Charge (pH 7.0)6.74

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.0120

GRAVY Index-0.65

Hydrophobic Moment 0.81

Boman Index-0.11

Instability Index39.23

Aliphatic Index 67.98

Aromaticity 0.0710

Extinction Coeff. Reduced 83880.00

Extinction Coeff. Oxidized 84380.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417497 VERIFIED: YES

Provenance & Taxonomy

OrganismEscherichia coli [Bacterium]

FamilyColicin/Pyocin

Tax ID562

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Antibiotic Bacteriocin Hydrolase Non-hemolytic Non-ribosomal

TargetEscherichia coli (Gram-negative)