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MYP_107048
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Basic Information
Hymenochirin-1B [P5K,E6K]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
29 amino acids
C141H261N39O35S
Standard
Sequence
IKLSKKTKDNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3094.89 Da
10.54
7.75
7.54
0.2673
0.08
0.69
-0.03
-8.38
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1233.15
-8.80
43.0
44.0
117.0
216.0
0.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017871 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human lung carcinoma A549
1.1
LC50
PMID24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24185042/
RECORD: Rec_0049370 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus ATCC 29213
3.1 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0050516 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Proteus mirabilis ATCC 25933
100 μM
MIC
PMID24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24185042/
RECORD: Rec_0079756 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
3.1 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0080057 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
baumannii
3.1 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
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