Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2294H3621N613O645S9

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIAILEKELAQLKLPDISGDSRVLRVGKVHYALSRLRLRDFHLPYSRITPISNVGLQVSISNAFAELDGDWRVKFLFVRDHGSFNLKVENIYIKIILQLGSDTAGKPTISSSDCSASISKVRVLFSGKFGWLYNLFHSAIESRLRKILQDKVCENVAKSVHDELQTYIRTLPVTARIDDKIGIDYSLVAPPRATAQSLDADLKGEFYSLAHRSSIPFSPLPLAFPSDHDRMVYFGASSYFFNTAGIAYNKAGALVFEITEAMIPKDAGFSLDTSIFSAFVPQLEDMYPNMPMKFRLSAPTAPFLTIGPGGISFQPIVDAQAYAILPDSSLAPLFLLSLVRNVSAVINVRSGHIVGSLDVGRIRLSLKDSAVGTFQVRTMQSLMNILASSTLLPRLNARLDEGFPLPLLDRIQLSNIIVKFHQNFLLLGADVHFQPR
    

Molecular Weight50396.59 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)6.37

Net Charge (pH 7.4) 5.51

Charge Density (pH 7.0) 0.0140

GRAVY Index0.13

Hydrophobic Moment 0.63

Boman Index0.11

Instability Index37.76

Aliphatic Index 105.66

Aromaticity 0.0943

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0275828 VERIFIED: NO

Provenance & Taxonomy

OrganismTichodroma muraria [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria