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MYP_106952
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Basic Information
Scapularisin-3
Antimicrobial
Antimicrobial ▸ Antifungal
Standard
38 amino acids
C181H289N67O50S6
Standard
Sequence
AFGCPFDQGTCHSHCRSIRRRGRRCASFAKRTCTCYQK
Physicochemical Analysis
4396.04 Da
9.99
7.91
7.53
0.2081
-0.83
0.85
-0.38
101.17
18.16
0.1053
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1939.02
-26.75
79.0
66.0
144.0
304.0
7.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010524 VERIFIED: YES
Provenance & Taxonomy
Ixodes scapularis [Animal]
Scapularisin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
PaperParasit Vectors. 2014 Dec 3;7(1):554 | http://www.ncbi.nlm.nih.gov/pubmed/25443032 PMID25443032 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25443032/
RECORD: Rec_0150607 VERIFIED: YES
Provenance & Taxonomy
Ixodes scapularis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
ed germination of F. culmorum
0.5 μM
IC50
PaperDefensins from the tick Ixodes scapularis are effective against phytopathogenic fungi and the human bacterial pathogen Listeria grayi.
RECORD: Rec_0173093 VERIFIED: YES
Provenance & Taxonomy
Ixodes scapularis [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0292822 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]; Arthropoda [Animal]
9031; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID25443032 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25443032/
RECORD: Rec_0305334 VERIFIED: YES
Provenance & Taxonomy
Ixodes scapularis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
Fusarium graminearum
1 μM
IC50
PaperDefensins from the tick Ixodes scapularis are effective against phytopathogenic fungi and the human bacterial pathogen Listeria grayi.
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