Peptide Database

Peptide NameT1568(FIV envelope protein (725-759))

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC193H285N51O60S

DescriptionStandard

        WNHGNITLGEWYNQTKDLQQKFYEIIMDIEQNNVQ
    

Molecular Weight4311.70 Da

Isoelectric Point (pI)4.50

Net Charge (pH 7.0)-3.15

Net Charge (pH 7.4) -3.41

Charge Density (pH 7.0) -0.0899

GRAVY Index-1.02

Hydrophobic Moment 0.59

Boman Index-0.06

Instability Index57.34

Aliphatic Index 75.14

Aromaticity 0.1429

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1863.34

LogP -16.35

H-bond Donors 60.0

H-bond Acceptors 59.0

Rotatable Bonds 145.0

Heavy Atoms 305.0

Ring Count 8.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0349533 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-FIV Fusion inhibition

TargetFeline immunodeficiency virus (FIV) | FIV/CrFK cells; HeLa cells

Activity0.971 μM

MethodEC90

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/

RECORD: Rec_0390481 VERIFIED: YES