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MYP_106702
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Basic Information
Brevinin-1CDYa (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
20 amino acids
C107H181N23O22S2
Standard
Sequence
LLSLALAALPKLFCLIFKKC
Physicochemical Analysis
2205.85 Da
9.39
2.74
2.50
0.1369
1.65
0.56
0.45
17.00
171.00
0.1000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
0.27
26.0
27.0
73.0
154.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003583 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
12.5 μM
MIC
PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
RECORD: Rec_0012028 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
Hemolysis
PMID19179051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19179051/
RECORD: Rec_0014209 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
RECORD: Rec_0046390 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
Brevinin
79015
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
12.5 μM
MIC
PaperIdentification and characterisation of a novel antimicrobial polypeptide from the skin secretion of a Chinese frog (Rana chensinensis).
RECORD: Rec_0066281 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
125 μM
HC50
PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
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