Peptide Database

Peptide NameSLAY-screened peptide P3182

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC52H92N16O18S3

DescriptionStandard

        RQETCISICCGL
    

Molecular Weight1325.58 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-0.27

Net Charge (pH 7.4) -0.52

Charge Density (pH 7.0) -0.0222

GRAVY Index0.57

Hydrophobic Moment 0.20

Boman Index0.07

Instability Index41.27

Aliphatic Index 97.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 566.17

LogP -6.94

H-bond Donors 23.0

H-bond Acceptors 21.0

Rotatable Bonds 44.0

Heavy Atoms 89.0

Ring Count 0.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0361647 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/