Peptide Database

Peptide NameSLAY-screened peptide P2260

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC93H161N29O31

DescriptionStandard

        TLARLTVDVSNLKKNHDGLS
    

Molecular Weight2181.45 Da

Isoelectric Point (pI)8.29

Net Charge (pH 7.0)0.49

Net Charge (pH 7.4) 0.24

Charge Density (pH 7.0) 0.0243

GRAVY Index-0.38

Hydrophobic Moment 0.49

Boman Index-0.11

Instability Index-2.26

Aliphatic Index 112.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1000.54

LogP -12.31

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 75.0

Heavy Atoms 153.0

Ring Count 1.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322348 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/