Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2386H3798N618O664S16

DescriptionStandard

        DNGEKMLKTWYSILLCWLSLQLEANPGLKVRITQKGLDYGRRIGMELLKQAVLKETFPSWSGQESFSVVKVNYVISRLRINAVDFPETSASFIPGIGISLSVAHASATISADWRMNAWLLKDQGGITVSISGLFIAVIFKVSRNSTGRLSMLLHSCQLSINSVKVKLNGGSSWIYSFLSGYLEKPIHTKLDKNLCLNIKNKIQMMDAQLRKHKVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFALPNQGDSMLYLGVSSYFLKSASLAYYRAGAFNIIISEELATTFNLHTTLFKDFVPEIALSYVTACPVLLKLMATSPPAVSLHADRCILQITGCVEVFAVLPNSTTQYIFTGNLTASTRANLTITKQKLIISLLLKRLQFSLLHSTLRFSEMSLVENFLSYALQSAVIPRINDKLGKGFPLLNLAHTTLTGPVIKMNQGHLVIATDVHYK
    

Molecular Weight52278.46 Da

Isoelectric Point (pI)9.48

Net Charge (pH 7.0)16.76

Net Charge (pH 7.4) 15.76

Charge Density (pH 7.0) 0.0354

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.16

Instability Index33.04

Aliphatic Index 109.05

Aromaticity 0.0909

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55725.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0195648 VERIFIED: NO

Provenance & Taxonomy

OrganismFulmarus glacialis [other]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria