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MYP_106605
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Basic Information
Dicynthaurin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C139H242N36O41S
Standard
Sequence
ILQKAVLDCLKAAGSSLSKAAITAIYNKIT
Physicochemical Analysis
3105.69 Da
9.52
2.75
2.52
0.0915
0.64
0.52
0.21
42.03
133.67
0.0333
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1256.16
-12.02
45.0
45.0
107.0
217.0
1.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0298287 VERIFIED: YES
Provenance & Taxonomy
Halocynthia aurantium [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Mostly C-terminally amidated. There is an intermolecular disulfide bond as well
Bio-Activity Profile
Antimicrobial
Listeria monocytogenes, Staphylococcus aureus. Antimicrobial robustness: NaCl-sensitive:Escherichia coli (100 mM), NaCl-sensitive:Pseudomonas aeruginosa (100 mM), NaCl-sensitive:Listeria monocytogenes (100 mM), NaCl-sensitive:Staphylococcus aureus (100 mM). Structure: Either the monomer
PaperDicynthaurin: an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium.
RECORD: Rec_0310563 VERIFIED: YES
Provenance & Taxonomy
Halocynthia aurantium [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Has hemolytic activity
Hemolysis
PMID11479030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11479030/
RECORD: Rec_0316448 VERIFIED: YES
Provenance & Taxonomy
Halocynthia aurantium [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
PaperPubMed PMID: 11479030 PMID11479030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11479030/
RECORD: Rec_0343984 VERIFIED: YES
Provenance & Taxonomy
Halocynthia aurantium [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Listeria monocytogenes
PMID11479030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11479030/
RECORD: Rec_0357901 VERIFIED: NO
Provenance & Taxonomy
Halocythia aurantum [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
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