Peptide Database

Peptide NameDicynthaurin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC139H242N36O41S

DescriptionStandard

        ILQKAVLDCLKAAGSSLSKAAITAIYNKIT
    

Molecular Weight3105.69 Da

Isoelectric Point (pI)9.52

Net Charge (pH 7.0)2.75

Net Charge (pH 7.4) 2.52

Charge Density (pH 7.0) 0.0915

GRAVY Index0.64

Hydrophobic Moment 0.52

Boman Index0.21

Instability Index42.03

Aliphatic Index 133.67

Aromaticity 0.0333

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1256.16

LogP -12.02

H-bond Donors 45.0

H-bond Acceptors 45.0

Rotatable Bonds 107.0

Heavy Atoms 217.0

Ring Count 1.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0137421 VERIFIED: YES

Provenance & Taxonomy

OrganismHalocynthia aurantium [Animal]

FamilyDicynthaurin

Structure & Mods

Configlinear peptide; intermolecular disulfide-linked homodimer [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation (major native form)

Disulfide9-9' (intermolecular homodimer)

Other ModsIntermolecular disulfide-linked homodimer; major native form C-terminally amidated

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

RECORD: Rec_0190567 VERIFIED: YES

Provenance & Taxonomy

OrganismHalocynthia aurantium [Animal]

FamilyDicynthaurin

Structure & Mods

Configlinear peptide; intermolecular disulfide-linked homodimer [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation (major native form)

Disulfide9-9' (intermolecular homodimer)

Other ModsIntermolecular disulfide-linked homodimer; major native form C-terminally amidated

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

RECORD: Rec_0202599 VERIFIED: YES

Provenance & Taxonomy

OrganismHalocynthia aurantium [Animal]

FamilyDicynthaurin

Structure & Mods

Configlinear peptide; intermolecular disulfide-linked homodimer [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation (major native form)

Disulfide9-9' (intermolecular homodimer)

Other ModsIntermolecular disulfide-linked homodimer; major native form C-terminally amidated

Bio-Activity Profile

Function

Antimicrobial

TargetHuman erythrocytes

Activity50 μg/mL

MethodHemolysis

RECORD: Rec_0208178 VERIFIED: YES

Provenance & Taxonomy

OrganismHalocynthia aurantium [Animal]

FamilyDicynthaurin

Tax ID33208; 7898

Structure & Mods

Configlinear peptide; intermolecular disulfide-linked homodimer [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation (major native form)

Disulfide9-9' (intermolecular homodimer)

Other ModsIntermolecular disulfide-linked homodimer; major native form C-terminally amidated

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0223217 VERIFIED: YES

Provenance & Taxonomy

OrganismHalocynthia aurantium [Animal]

FamilyDicynthaurin

Structure & Mods

Configlinear peptide; intermolecular disulfide-linked homodimer [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation (major native form)

Disulfide9-9' (intermolecular homodimer)

Other ModsIntermolecular disulfide-linked homodimer; major native form C-terminally amidated

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

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