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MYP_106594
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Basic Information
XPF-St8
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
25 amino acids
C121H196N34O31S2
Standard
Sequence
GFMSKVANFAKKFAKGGVNAIMNQK
Physicochemical Analysis
2687.19 Da
10.60
4.76
4.54
0.1902
-0.13
0.73
0.06
16.29
54.80
0.1200
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1084.41
-10.87
36.0
38.0
95.0
188.0
3.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0306485 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Trypanosoma brucei[90-100% Killing = 01-8microM
PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0321339 VERIFIED: YES
Provenance & Taxonomy
Silurana tropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-positive
Staphylococcus aureus
128 μM
MIC
RECORD: Rec_0325735 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic Toxicity
to erythrocytes
64 μM
HC50
PaperOrigin and functional diversification of an amphibian defense Peptide arsenal. PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0366713 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 24.0%, E 0.0%, T 52.0%, C 24.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Antifungal Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0372121 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
moderate hemolytic and T-lymphocytes
16 μM
IC50
PaperOrigin and functional diversification of an amphibian defense Peptide arsenal. PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
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