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MYP_106575
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Basic Information
Brevinin-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiviral
Antiviral ▸ Virucidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C121H204N28O26S2
Standard
Sequence
FLPVLAGIAAKVVPALFCKITKKC
Physicochemical Analysis
2531.22 Da
9.70
3.74
3.50
0.1557
1.29
0.49
0.39
31.07
134.17
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-2.29
30.0
32.0
81.0
177.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0368706 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperMorikawa N., Hagiwara K., Nakajima T.;. "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa."; Biochem. Biophys. Res. Commun. 189:184-190. Evidence URLhttps://www.uniprot.org/uniprotkb/BR1_RANBP/entry
RECORD: Rec_0379110 VERIFIED: YES
Provenance & Taxonomy
Pelophylax porosus [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0385289 VERIFIED: NO
Provenance & Taxonomy
Pelophylax porosus brevipodus [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/; https://www.uniprot.org/uniprotkb/P32423/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0394418 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0411412 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda porsa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antiviral
Bacillus subtilis
2 μg/mL
MIC
PaperBrevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa.
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