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MYP_106575
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Basic Information
Brevinin-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiviral
Antiviral ▸ Virucidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C121H204N28O26S2
Standard
Sequence
FLPVLAGIAAKVVPALFCKITKKC
Physicochemical Analysis
2531.22 Da
9.70
3.74
3.50
0.1557
1.29
0.49
0.39
31.07
134.17
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-2.29
30.0
32.0
81.0
177.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0239688 VERIFIED: YES
Provenance & Taxonomy
Daruma pond [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0263099 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda porsa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antiviral
Escherichia coli
34 μg/mL
MIC
PaperBrevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa.
RECORD: Rec_0271520 VERIFIED: YES
Provenance & Taxonomy
Anura [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Herpes simplex virus 1 (Virucidal); Vero
Viral titer
PaperPeptide inhibitors against herpes simplex virus infections. | Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M. | J Pept Sci. 2013 | PMID:23389903 PMID23389903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23389903/
RECORD: Rec_0280886 VERIFIED: YES
Provenance & Taxonomy
Rana porosa brevipoda [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
8 μg/mL
MIC
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/
RECORD: Rec_0337358 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
80 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10795591/ PMID10795591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10795591/
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