Peptide Database

Peptide NamePR-FO (Derived from PRW4)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC201H334N74O33

DescriptionStandard

        RFRRLRWKTRWRLKKIRFGRFLRKIRRFRPK
    

Molecular Weight4315.28 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)16.75

Net Charge (pH 7.4) 16.54

Charge Density (pH 7.0) 0.5405

GRAVY Index-1.50

Hydrophobic Moment 1.06

Boman Index-0.81

Instability Index94.01

Aliphatic Index 62.90

Aromaticity 0.1935

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1852.24

LogP -11.09

H-bond Donors 75.0

H-bond Acceptors 50.0

Rotatable Bonds 151.0

Heavy Atoms 308.0

Ring Count 9.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0404060 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEnterococcus faecalis 29212

Activity1.1 μg/mL

MethodMIC

PaperCharacterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of α-helix-based peptide amphiphiles. Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063. PMID: 25818457. PMID25818457 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25818457/

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