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MYP_106521
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Basic Information
Ranalexin-1Cb
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
20 amino acids
C98H163N23O22S3
Standard
Sequence
FLGGLMKAFPAIICAVTKKC
Physicochemical Analysis
2111.68 Da
9.39
2.74
2.50
0.1369
1.20
0.43
0.40
30.68
107.50
0.1000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.86
26.0
28.0
69.0
146.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0263548 VERIFIED: YES
Provenance & Taxonomy
Rana clamitans [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
No MICs found in DRAMP database
PMID10822101 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10822101/
RECORD: Rec_0267964 VERIFIED: YES
Provenance & Taxonomy
Lithobates calamitans [Animal]
Ranalexin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-20
Bio-Activity Profile
Antimicrobial Antibacterial
PaperT. Halverson et al. / Peptides 21 (2000) 469-476. Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans Evidence URLhttps://www.uniprot.org/uniprotkb/P82877/entry
RECORD: Rec_0270570 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 35.0%, E 0.0%, T 30.0%, C 35.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0310731 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0354283 VERIFIED: YES
Provenance & Taxonomy
Lithobates clamitans [Animal]
Ranalexin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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